These freewheeling conversations are open to all via teleconference, and to as many folks as will fit around the tables . from 8 AM - 9 PM ET. These droplets form dynamically throughout the cell via a process called phase separation. Promote high levels of productivity and urgency, leading by personal example, Provide day-to-day technical guidance to a team of Medicinal Chemists and also work in the lab to synthetize NCEs, Maintain the highest levels of Health and Safety standards across the Chemistry group, Become a valuable contributor to other initiatives as they arise in our fast paced, startup environment, Doctorate degree in Organic Chemistry or Medicinal Chemistry with 5+ years of laboratory-based research experience, Experience in working across multiple target-types and gene families, Expertise in methodology development and multi-step synthesis, Track record of delivering high quality candidates into development, Strong knowledge of techniques related to purification and characterization of organic compounds, Ability to work closely with other experts (in CADD, Biology, DMPK, Safety, CMC) to identify key drug discovery issues, propose and implement creative solutions, and execute on innovative medicinal chemistry designs, Ability to analyze, interpret, and effectively present scientific data at team meetings, Ability to contribute at all stages of a project from early project validation, hit and lead optimization to candidate selection, Ability to suggest and lead changes to improve work process effectiveness at all levels and across disciplines, Proven track record of creative thinking and consistent delivery, Strong prioritization and problem-solving skills, Be highly self-motivated, proactive, curious, hard-working, Ability to collaborate in a multidisciplinary and dynamic environment and experience in mentoring and leading scientific team, Ability to communicate effectively in English, the shared language of our multicultural team, It is nice but not essential that you also have…. Total amount raised across all funding rounds, Total number of Crunchbase contacts associated with this organization, Total number of employee profiles an organization has on Crunchbase, Total number of investment firms and individual investors, Total number of organizations similar to the given organization, Descriptive keyword for an Organization (e.g. P granules segregate asymmetrically during embryogenesis. Aberrant condensate function has also been linked to human diseases, including neurodegeneration and cancers. Learn more at dewpointx.com, and follow us on . Corresponding authors are [email protected] and [email protected]. I have a voice here and I'm respected here. Patent advances Dewpoint's leadership in the discovery of biomolecular condensate modulators with vast potential to treat diseases, New technology is the first to measure how a compound is entering or partitioning into a condensate to selectively target a single molecule to alter disease. . Condensates play a critical role in a wide range of important diseases. Biomolecular condensates are molecular assemblies that form by a process called phase separation, similar to the separation of oil from water. Dewpoint Therapeutics GmbH, Dresden, Germany, District Court of Dresden HRB 40295: Network, Financial information. This can influence the activity of a drug by altering its local subcellular concentration, and thereby, its efficacy. You will identify and execute gating and triaging experiments for the identification, progression, and validation of hypotheses and drugs as well as create and execute on strategic flow-schemes to identify compounds that have desired effects/properties. Dewpoint scientists are working in Boston, MA, and Dresden and Frankfurt, Germany, to translate condensate biology into treatments for the toughest diseases. Condensate-targeted drug discovery was pioneered by Dewpoint Therapeutics as the first biotech company to enter the field, founded in 2018. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Scientist – Medicinal Chemistry (m/f/d), Enjoy working in a highly collaborative team environment, demonstrating exceptional teamwork skills and a “can-do” / “can-win” attitude, Experience and direct accountability in project leadership. In November 2019, Dewpoint announced a collaboration with Bayer, combining the potential of Dewpoint's condensate platform with Bayer's small molecule compound library to develop new treatments for cardiovascular and gynecological diseases. Dresden and Frankfurt to translate condensate biology into . Dewpoint believes that a vast range of conditions have pathways that are regulated by condensates or arise from the dysfunction of condensates. Voit muuttaa valintojasi milloin tahansa siirtymällä yksityisyydenhallinta-asetuksiisi. Dewpoint Therapeutics is the first company to apply the emerging understanding of biomolecular condensates to drug discovery. As part of our growing MedChem group you will provide key contributions to the implementation of medicinal chemistry strategies through the design, development, and execution of innovative chemistry and help to revolutionize our approach to the discovery and development of small molecules. Approaches to modulating condensates that may positively impact disease include dissolving or forming condensates, modulating the composition of condensates, stabilizing condensates, and selective drug delivery into condensates. This role will be based at our Chemistry & Drug Discovery site in Frankfurt, Germany. This breakthrough technology will direct a compound to selectively target a single molecule in a condensate to alter disease. Leading thinkers in cell biology, biophysics, drug discovery, and medicinal chemistry come together at Dewpoint. When something goes awry with a condensate’s composition or behavior, we call it condensatopathy. Dewpoint Therapeutics is the first company to apply the emerging understanding of biomolecular condensates to drug discovery. BOSTON, Nov. 14, 2022 /PRNewswire/ -- Dewpoint Therapeutics Inc. today announced the U.S. Patent and Trademark Office (USPTO) issued the patent "Methods of Characterizing Condensate-Associated Characteristics of Compounds and Uses Thereof" (U.S. Patent No. Condensates are membrane-less organelles that form dynamically throughout the cell via a process called phase separation. It's a new way of thinking about medicinal chemistry and lead optimization with the potential to improve drug efficacy.". Seed, Series A, Private Equity), Whether an Organization is for profit or non-profit, General contact email for the organization. Alle Dewpoint Therapeutics Jobs - Frankfurt am Main Stellenangebote anzeigen; Gehalt-Suche: Principal Scientist - Medicinal Chemistry (m/f/d) Gehälter in Frankfurt am Main; Innovation Cup 2023 - Team Medicinal Chemistry. Click the link in the email we sent to to verify your email address and activate your job alert. The round was led by ARCH Venture Partners, with participation from new investors Maverick Ventures and Bellco Capital, and existing investors Leaps by Bayer, EcoR1 Capital, Polaris Partners, Samsara BioCapital, and Innovation Endeavors. Sign in to create your job alert for Senior Principal Scientist jobs in Boston, MA. Dewpoint scientists are working in Boston, MA, and Dresden and Frankfurt, Germany, to translate condensate biology into treatments for the toughest diseases. Tietoja laitteestasi ja Internet-yhteydestä (esimerkiksi IP-osoitteesi), Selaaminen ja hakutoiminnot Yahoon verkkosivustojen ja -sovellusten käytön aikana. Merck KGaA Darmstadt Germany 3,8. Boston, MA, USA. from 8 AM - 9 PM ET. Based on these rules, the authors discuss how condensate dysfunction drives various diseases, including neurodegeneration, cancer, cardiomyopathy and viral infection. About Biomolecular Condensates Biomolecular condensates, formed through a process called phase separation, are membraneless droplets inside cells that facilitate molecular interactions and help cells perform vital functions. Dewpoint Therapeutics is the first company to apply the emerging understanding of biomolecular condensates to drug discovery. Dewpoint scientists are working in Boston, MA, and Dresden and Frankfurt, Germany, to translate condensate biology into treatments for the toughest diseases. Dewpoint currently has more than 20 development programs across an ambitious pipeline with programs spanning oncology, neuromuscular, cardiopulmonary and virology indications, and collaborations with leading global academic and pharmaceutical partners, including Bayer, Merck and Pfizer. Get email updates for new Senior Principal Scientist jobs in Boston, MA. The emerging science of biomolecular condensates could help answer some of biology’s biggest questions. Prior to Beam, Dr. Ciaramella served at Moderna, first as head of immunology and biotherapeutics, then as chief scientific officer of its infectious diseases division. Scientist, Bio Analytical Sciences, See who Dewpoint Therapeutics has hired for this role, Define project-related Medicinal Chemistry strategies and define overall strategy for highly innovative drug discovery projects from Target ID to hit identification to candidate nomination, Promote and maintain the highest levels of excellence in medicinal chemistry, demonstrating a personal commitment to extending and developing knowledge and expertise, Lead and/or contribute to cross-site functional goals within Chemistry & Drug Discovery, Analyze screening data, establish SAR, perform literature reviews, design, and implement medicinal chemistry plans, coordinate chemistry and biology data to support compound progression and IP strategies, Effectively manage external resources at our partner CROs, Together with the MedChem team, use timely decision-making to ensure focus and delivery of key objectives across the portfolio, Demonstrate teamwork and promote an open and innovative culture within a cross discipline environment, Become a valuable contributor to other corporate initiatives as they arise in our fast paced, startup environment, PhD in Organic Chemistry with 5+ years of laboratory-based research experience, preferably in a biopharmaceutical setting, Expertise in methodology development and complex multi-step synthesis, Experience in working across multiple target-types and gene families, Ability to work closely with other drug discovery experts (in CADD, Biology, DMPK, Safety, CMC) to identify key project issues, propose and implement creative solutions, and execute on innovative Medicinal Chemistry designs, Ability to analyze, interpret, and effectively present scientific data, Ability to contribute at all stages of a project from early target validation, hit and lead optimization to candidate selection, Proven track record of creative thinking and consistent delivery with strong prioritization and problem-solving skills, Enjoy working in a highly collaborative team environment, demonstrating exceptional teamwork skills and a "can-do" / "can-win" attitude, Ability to communicate effectively in English, the shared language of our multicultural team, Experience and direct accountability in project leadership, Drug discovery experience in oncology and neuroscience. It is only in the last dozen years, though, that scientists—including Dewpoint founders Tony Hyman of the Max Planck Institute in Dresden and Rick Young of the Whitehead Institute—have begun to understand the dynamic nature and function of condensates. Dewpoint Therapeutics is the first company to apply the emerging understanding of biomolecular condensates to drug discovery. Dewpoint believes that a vast range of conditions have pathways that are regulated by condensates or arise from the dysfunction of condensates. It is nice but not essential that you also have... Dewpoint Therapeutics is the first company founded to apply the emerging discipline of biomolecular condensates to drug discovery. DENVER & BOSTON-- ( BUSINESS WIRE )--Palantir Technologies Inc. (NYSE: PLTR), a . December 20, 2021 06:59 AM Eastern Standard Time. In this position you’ll be part of an energizing and supportive startup culture engaged in continuous learning, and part of an exceptional international team. Dewpoint Therapeutics is the first company founded to apply the emerging discipline of biomolecular condensates to drug discovery. Classical drug discovery focuses on modifying the function of a single target biomolecule. Candidates will not be discriminated against on the basis of age, race, creed, color, religion, sex, sexual orientation, national origin, disability, marital status, or any other basis prohibited by federal, state, or local law. Scientist, Medicinal Chemistry, Tumor Targeted Delivery, Process Development - Principal Scientist - AD (Boston), Principal Scientist, Analytical Technology, Principal Scientist, Sustainable Chemicals, Principal Scientist, Analytical Research and Development, Scientist/Sr. Jeanette BressiHead, Communications & PR | Dewpoint Therapeutics609-439-3997[email protected], Cision Distribution 888-776-0942 Dewpoint Therapeutics GmbH +49 69 305 31055; www.dewpointx.com; Industriepark Höchst Building G 830, Room 207/209 65926 Frankfurt am Main Contact. Together, we are leveraging a transformative shift in the understanding of cellular biology to discover and advance breakthrough therapeutics for the toughest diseases. . Candidates will not be discriminated against on the basis of age, race, creed, color, religion, sex, sexual orientation, national origin, disability, marital status, or any other basis prohibited by federal, state, or local law. Dewpoint Therapeutics translates condensate biology into much-needed medicines. Phil Sharp identifies condensate biology as a once-in-a-generation opportunity to make transformative new medicines. Dieses Profil melden Melden Melden. Dewpoint Therapeutics is a biotech company developing a drug platform that targets biomolecular condensates. Dewpoint believes that a vast range of conditions have pathways that are regulated by condensates or arise from the dysfunction of condensates, with programs spanning oncology, neuromuscular, cardiopulmonary, and virology indications. Dewpoint Therapeutics 451 D Street, Suite 104 Boston, MA 02210 info@dewpointx.com Dewpoint Therapeutics is the first company to apply the emerging understanding of biomolecular condensates to drug discovery. New rules for the design of condensate modifying therapeutics are continuously evolving along with the new discoveries in the field. At Dewpoint, we translate condensate biology into much-needed medicines. Its technology uses machine-learning-based image analysis tools for visualizing condensates and offers an engine for genetically linked condensatopathy which is a collection of engineered cell lines with trackable condensates to prevent. Authors for the article include Diana M. Mitrea, Matthäus Mittasch, Beatriz Ferreira Gomes, Isaac A. Klein and Mark M. Murcko. Dewpoint believes that a vast range of conditions have pathways that are regulated by condensates or arise from the dysfunction of condensates — including cancer, neurodegeneration, and metabolic disease. Referrals increase your chances of interviewing at Dewpoint Therapeutics by 2x. In addition to announcing its Series B, Dewpoint today announced the addition of Giuseppe Ciaramella, Ph.D., to its Board of Directors. Dewpoint scientists are working in Boston, MA, and Dresden and Frankfurt, Germany, to translate condensate biology into treatments for the toughest diseases. Engine for genetically linked condensatopathy discovery, Machine-learning-based image analysis tools for visualizing condensates, Proprietary knowledge base of biomolecules in condensates, Compendium of all condensates in different cell types, Collection of engineered cell lines with trackable condensates, Suite of reconstituted physiologically relevant cell-free condensates, Methods for monitoring drug partitioning into condensates, Integrated machine learning platform automates, speeds, and enhances c-mod discovery, Discovering and developing c-mods to address true unmet need, Multiple solid and liquid tumors Wholly owned, Rare diseases and repeat expansion disorders Wholly owned, Building on condensate science, from concept to company. Dewpoint currently has more than 20 development programs across an ambitious pipeline with programs spanning oncology, neuromuscular, cardiopulmonary and virology indications, and collaborations with leading global academic and pharmaceutical partners, including Bayer, Merck and Pfizer. "This new platform technology holds the potential to revolutionize the treatment of a multitude of diseases by identifying molecules which alter the specific components of biomolecular condensates with high precision," commented Dr. Isaac Klein, Chief Scientific Officer at Dewpoint. In addition to disease areas where Dewpoint has announced collaborations, the company is exploring potential therapeutic opportunities in oncology, neurodegeneration, metabolic disease, and immunology. The large financing is a bet on Glick's track . Dewpoint’s issued patent is the first patented technology for measuring how a compound is entering or partitioning into a target condensate. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Condensate behavior is governed by the concentrations of, and multivalent interactions between, proteins and nucleic acids. Biomolecular condensates can fuse over time. No longer accepting applications. Strong publication record in peer-reviewed journals and/or evidence of sustained contributions to the field. Posted 6 months ago. Dewpoint scientists work in Boston, Dresden and Frankfurt to translate . Dewpoint believes that a vast range of conditions have pathways that . Dewpoint believes that a vast range of conditions have pathways that are regulated by condensates or arise from the dysfunction of condensates — including cancer, neurodegeneration, and metabolic disease. See open jobs. Little has been known about the mechanisms governing the partitioning of compounds into condensates, how to design and test compounds to improve interactions with condensates, and how such information can be used to improve treatment of diseases. It’s a new way of thinking about medicinal chemistry and lead optimization with the potential to improve drug efficacy.”. Dewpoint scientists work in Boston, Dresden, and Frankfurt to translate condensate biology into treatments for the toughest diseases. Candidates will not be discriminated against on the basis of age . | Dewpoint Therapeutics is the first company to apply the emerging understanding of biomolecular condensates to drug discovery. Vollzeit. Dewpoint Therapeutics has an anti-hate policy in place, along with an active staff-led Diversity, Equity, and Inclusion Committee sponsored by the CEO. Principles and functions of condensate modifying drugs. This breakthrough technology will direct a compound to selectively target a single molecule in a condensate to alter disease. Biomolecular condensates are molecular assemblies that form by a process called phase separation, similar to the partitioning of oil from water. . Dewpoint Therapeutics | 5,933 (na) tagasubaybay sa LinkedIn. Cision Distribution 888-776-0942 BOSTON, May 25, 2022 /PRNewswire/ -- Dewpoint Therapeutics Inc., today announced the US Patent and Trademark Office (USPTO) issued the patent "Methods of Screening for Condensate-Associated Specificity and Uses Thereof" (U.S. Patent No. From time to time, the scientists at Dewpoint, in partnership with Condensates.com, invite researchers from around the condensates community to sit down with us at our kitchen table and talk about science. . The latest Tweets from Dewpoint Therapeutics (@dewpoint_tx). Giuseppe Ciaramella, Ph.D., joins Board of Directors, Since 2019 launch, the company has also announced collaborations with Bayer and Merck. Define project-related Medicinal Chemistry strategy and define overall strategy for highly innovative drug discovery projects from Target ID to hit identification to candidate nomination, Promote and maintain the highest levels of excellence in medicinal chemistry, demonstrating a personal commitment to extending and developing knowledge and expertise, Lead and/or contribute to cross-site functional goals within Chemistry & Drug Discovery, Analyze screening data, establish SAR, perform literature reviews, design, propose, and execute medicinal chemistry plans, coordinate chemistry and biology data to support compound progression and patent strategies, Advise, coordinate, and steer external resources at our partner CROs. Over the last decade scientists have recognized the role of biomolecular condensates in cellular organization and disease, marking one of the most revolutionary areas of biology. Dewpoint Therapeutics is a biotech company developing a drug platform that targets biomolecular condensates. Zurück Senden. "Dewpoint is the international center of gravity for developing and translating condensate science into drugs," said Kristina Burow, managing director at ARCH Venture Partners. Environmental, Social and Governance (ESG), HVAC (Heating, Ventilation and Air-Conditioning), Machine Tools, Metalworking and Metallurgy, Aboriginal, First Nations & Native American, Dewpoint Therapeutics Granted Second Breakthrough Condensates Platform Technology Patent by US Patent Office, Breakthrough Prize in Life Sciences awarded to Anthony Hyman, Ph.D., pioneer of biomolecular condensates and co-founder of Dewpoint Therapeutics. full time. Scientists or investors interested in biomolecular condensates can also visit condensates.com for news and updates in the field. "This collection of drug hunters is a powerful force.". Frankfurt am Main und Umgebung, Deutschland Classical Medicinal Chemistry in lead finding and optimization programs based on HTS-approaches, rational drug design and rescaffolding of literature compounds. 64293 Darmstadt. Johannes Gutenberg-Universität Mainz. Kun napsautat Hyväksy kaikki, hyväksyt sen, että Yahoo ja kumppanimme käsittelevät henkilötietojasi ja näyttävät evästeiden kaltaisten tekniikoiden avulla sinulle räätälöityä mainontaa ja sisältöä sekä hyödyntävät näitä tekniikoita mainosten ja sisällön mittaamisessa, kohderyhmätiedoissa ja tuotekehityksessä. Dresden and Frankfurt with a shared vision to translate condensate . Dewpoint Therapeutics is an equal opportunity employer committed to the principles of non-discrimination in the workplace. Condensate science holds broad promise for both understanding the origin of diseases and the discovery of breakthrough treatments. In July 2020, Dewpoint announced an exclusive collaboration with Merck (MSD) to leverage Dewpoint's proprietary biomolecular condensate platform for the development of a novel mechanism for the treatment of HIV.
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