Applies only to oral form of both agents. Either decreases levels of the other by inhibition of GI absorption. 4)Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Applies only to oral form of both agents. Use Caution/Monitor. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Pediatric Patients (2 Years of Age and Older). Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. Applies only to oral form of both agents. . Applies only to oral form of both agents. If you log out, you will be required to enter your username and password the next time you visit. Suggested regime: Prescribing instructions Prescribing a single/first dose: calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Use Caution/Monitor. Venofer treatment may be repeated if necessary. Maximum infusion rate: 100 mg / hour (Slow infusion rate of iron sucrose is recommended to minimize adverse reactions, especially hypotension) Frequency of infusion: Dose may be repeated up to 3 times weekly to provide total iron dose. Treatment of anemia due to iron deficiency. 1. 1996 Aug;11(4):139-46. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Monitor Closely (1)lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor. INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. iron sucrose decreases levels of ibandronate by inhibition of GI absorption. 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Use Caution/Monitor. Each mL contains 20 mg of elemental iron. Hollands J, Foote E, Rodriguez A. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Minor/Significance Unknown. Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. Applies only to oral form of both agents. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. 3. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Baloxavir may bind to polyvalent cations resulting in decreased absorption. For all products, slow initial infusion is prudent; the patient is observed closely for infusion reactions. If we don't have the calculator you need we'll try to make it for you and add it to the website. Applies only to oral form of both agents. Use Caution/Monitor. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. IMPORTANT SAFETY INFORMATION DOSAGE AND ADMINISTRATION Pediatric Patients (2 Years of Age and Older) J Med. Do not double the dose to catch up. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Human studies not conducted. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. Use Caution/Monitor. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Fill in the calculator/tool with your values and/or your answer choices and press Calculate. however iron sucrose requires multiple small intermittent doses over days to weeks. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. 5. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. Applies only to oral form of both agents. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. The dosage of iron sucrose is expressed in mg of elemental iron. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Serious - Use Alternative (1)iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Modify Therapy/Monitor Closely. 10th ed. Talk to your pharmacist for more details.During pregnancy, this medication should be used only when clearly needed. Contraindicated. We have found the lower dose to be better tolerated in the second half of gestation. iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Monitor Closely (1)iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. It should be recognized that iron storage may lag behind the appearance of normal blood morphology. Separate by 2 hr. prescription products. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. Jacobs P, Dommisse J. Applies only to oral form of both agents. Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Separate dosing of tetracyclines from these products. There are four fields that need to be completed: Weight body weight is used to establish iron deficit and is also taken into account when estimating the iron stores. Avoid or Use Alternate Drug. Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products (such as Venofer) which may cause fetal bradycardia, especially during the second and third trimester. There are physiological variation in iron reserves such as the decrease during menstruation period. Venofer treatment may be repeated if iron deficiency reoccurs. Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. Due Date form Ultrasound Report. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. Dosing: (a) Divide calculated total cumulate dose . The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. After administration of iron dextran complex, evidence of a therapeutic response can be seen in a few days as an increase in the reticulocyte count. Please confirm that you would like to log out of Medscape. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. Do not administer Venofer to patients with evidence of iron overload. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Minor/Significance Unknown. Contraindicated. Applies only to oral form of both agents. Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 - Hb in g/dL) x 2.145 Volume of product required in mL = Iron deficit in mg / C in mg/mL Where C is the concentration of the iron product: 50 mg/mL for Iron dextran; 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . Venofer may cause clinically significant hypotension. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. Applies only to oral form of both agents. Generic name: IRON SUCROSE 20mg in 1mL May increase risk of hypotension. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. . Use Caution/Monitor. Separate by 2 hr. For patients receiving hemodialysis, administer Feraheme once the blood pressure is stable and the patient has completed at least one hour of hemodialysis. By using this form you agree with the storage and handling of your data by this website. Patients measured hemoglobin can be input in g/dL or mmol/L. Can't find what you need? Venofer is manufactured under license from Vifor (International) Inc., Switzerland. 2010;18(3). informational and educational purposes only. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Fatal reactions have also occurred in situations where the test dose was tolerated. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of . 1982;13(4):309-21. This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement. Modify Therapy/Monitor Closely. ADMINISTER THE TEST DOSE AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. Administer on 5 different occasions over a 14 day period. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? Test Dose: Not required. Included in the iron dextran package insert. 2000 Jan;22(1):39-43. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. This product may contain inactive ingredients, which can cause allergic reactions or other problems. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. Applies only to oral form of both agents. Monitor Closely (1)omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. Kidney Int. Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. Copyright 1993-2021 Manage and view all your plans together even plans in different states. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. World J Gastroenterol; 16(22): 27202725. Applies only to oral form of both agents. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. STORAGE: Consult the product instructions and your pharmacist for storage details. 1 Dosing for patients who weigh less than 50 kg Applies only to oral form of both agents. Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or Venofer (Iron Sucrose Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Monitor patients for signs and symptoms of hypersensitivity during and after Venofer administration for at least 30 minutes and until clinically stable following completion of the infusion. Kumpf VJ. 1970; 100(7):301-3. There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption.